This morning I had a nice bug to track down, for some reason the intranet web application was failing for users in a certain role. I've got an exception handling block which is shared amongst all new internal applications (webapps and winforms) which allows exceptions to be logged to a server (via .NET Remoting rather than webservices) so getting access to the bugger is easy, unless of course the service can't be reached and in such case exceptions are logged in the Event Log and unless someone notifies me of a problem I have no way of knowing (I could cache the exceptions locally and retry at a later time when the service is backup but I never implemented it).

Could not load file or assembly 'App_Web_afcjvzm7, Version=0.0.0.0, Culture=neutral, PublicKeyToken=null' or one of its dependencies. The system cannot find the file specified.

A quick google search uncovered a thread on aspnet with a fair number of people suffering the same problem, it appears there is a hotfix available which is claimed to fix the problem, but noone has verified it does. The only solution in the short term seems to be to make a modification to the file thats causing the problem, which isn't very practicable in the long run.